Blood 2011 117: 6445–6449.ĭ'Souza A, Lacy M, Gertz M, Kumar S, Buadi F, Hayman S et al. Combination of melphalan and dexamethasone for patients with newly diagnosed POEMS syndrome. Li J, Zhang W, Jiao L, Duan MH, Guan HZ, Zhu WG et al. The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome. Lancet 1996 347: 702.ĭ'Souza A, Hayman SR, Buadi F, Mauermann M, Lacy MQ, Gertz MA et al. Greatly raised vascular endothelial growth factor (VEGF) in POEMS syndrome. Watanabe O, Arimura K, Kitajima I, Osame M, Maruyama I. Renal impairment in patients with polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes syndrome: incidence, treatment and outcome. Ye W, Wang C, Cai QQ, Cai H, Duan MH, Li H et al. Pulmonary hypertension in POEMS syndrome. ![]() Li J, Tian Z, Zheng HY, Zhang W, Duan MH, Liu YT et al. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Li J, Zhou DB, Huang Z, Jiao L, Duan MH, Zhang W et al. POEMS syndrome: definitions and long-term outcome. Am J Hematol 2014 89: 214–223.ĭispenzieri A, Kyle RA, Lacy MQ, Rajkumar SV, Therneau TM, Larson DR et al. POEMS syndrome: 2014 update on diagnosis, risk-stratification, and management. New advances in the diagnosis and treatment of POEMS syndrome. This nomogram could be a useful and convenient tool in clinical practice to evaluate individualized prognosis in patients with newly diagnosed POEMS syndrome. Concordance index calculation (0.727, 95% CI 0.601–0.853, P=0.018) and calibration curve plotting demonstrated its significant predictive and discriminatory capacity in the validation cohort. These factors were incorporated together to develop a prognostic nomogram. On the basis of a randomized sample splitting, we first identified four baseline clinical variables, including age >50 years (hazards ratio (HR) 4.07, 95% confidence interval (CI) 1.41–11.76, P=0.009), pulmonary hypertension (HR 3.99, 95% CI 1.44–11.04, P=0.008), pleural effusion (HR 3.81, 95% CI 1.23–11.79, P=0.02) and estimated glomerular filtration rate <30 ml/min/1.73 m 2 (HR 8.25, 95% CI 2.18–31.25, P=0.002), associated with inferior overall survival in the derivation cohort, with the use of multivariate Cox regression model. We retrospectively included 362 patients with newly diagnosed POEMS syndrome at our institute from 2000 to 2015. In its dozens of clinical features, those with independent prognostic value are still not well characterized. 6.1).POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal gammopathy and skin changes) is a multisystem disorder with a good long-term prognosis. This chapter begins with design descriptions for prognostics studies, as these will be different from the types of designs used for intervention studies ( Fig. ![]() The prognostic literature has specific types of designs and statistical analyses. ![]() Valid prognostic studies can assist in answering these types of questions, and they assist in weighing the various factors that may contribute to specific outcomes. You may ask, "What is the prognosis for my patient to return home versus a rehabilitation facility at discharge?" or "What are the odds that this intervention will benefit my patient's independent ambulation?" Many factors influence the answers to prognostic questions such as the severity of the patient's problem, gender, age, home environment, and co-morbidities. For example, a patient may ask, "Will I be able to ski after back surgery?" or "When can I expect to go back to work?" Prognostic questions may also guide discharge planning. Prognostic questions may be about the impact of a disease or event on a patient's long-term outcome. Patients, families, and physical therapists have many questions about prognosis.
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |